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• ↓ Design and interpretation of eQTL-GWAS colocalisation studies: Lessons from a large-scale evaluation
• ↓ KAT6A is essential for developmental control gene expression in neural stem and progenitor cells
• ↓ NS-17 acts as a nutrient deprivation signal to mediate adult IIS-regulated associative behaviors in C. elegans
• ↓ Translation control by altered start codon usage as a means of modulating the general stress response and virulence in Listeria monocytogenes
• ↓ System drift in the evolution of plant meristem development
• ↓ Post-translational modifications of GlmR integrate metabolic and stress signals to maintain cell envelope homeostasis in Bacillus subtilis
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"Most of the genetic variants associated with complex traits are located outside genes, limiting functional interpretation. Genetic colocalisation helps identify candidate causal genes by testing whether the same variant influences a complex trait and the expression of a nearby gene (eQTL)."

"During embryonic development, specific families of transcription factors pattern the early embryo to lay down and define the body and organ structure. However, the mechanisms governing the onset of the expression of these developmental transcription factors in less well understood. KAT6A is thought to promote gene expression by acetylation histone proteins."

"Insulin signaling is a diverse actor that regulates many processes essential for life from growth and development, aging, cognition, among many others. However, how insulin signaling regulates myriad processes across tissues within an organism is poorly understood. Simple models, like the nematode worm C. elegans, highlight the diversity of insulin signaling function."

"The general stress response (GSR) in foodborne pathogen Listeria monocytogenes is important for environmental stress response and for host entry, but GSR is also highly variable across wild isolates."

Key Topics & Focus Areas for plosgenetics.org:

Design and interpretation of eQTL-GWAS colocalisation studies: Lessons from a large-scale evaluation

KAT6A is essential for developmental control gene expression in neural stem and progenitor cells

NS-17 acts as a nutrient deprivation signal to mediate adult IIS-regulated associative behaviors in C. elegans

Translation control by altered start codon usage as a means of modulating the general stress response and virulence in Listeria monocytogenes

System drift in the evolution of plant meristem development

Post-translational modifications of GlmR integrate metabolic and stress signals to maintain cell envelope homeostasis in Bacillus subtilis