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Table of Contents

• ↓ Gut Microbiome Composition Correlates with Epigenetic Clock Results
• ↓ A View of Aging Centered Around the Role of Karyopherins and Nuclear Transport
• ↓ Reviewing Age-Related Changes in Microglia
• ↓ Quantifying the Risk of Alzheimer's Disease Associated with High Levels of p-tau217 in Blood
• ↓ How to Go About Measuring Health in Aging is its Own Sizable Debate
• ↓ CMLase Enzyme Developed to Break Down CML Advanced Glycation Endproducts
• ↓ Top Alternatives to fightaging.org

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"Do you want to live a longer life in good health? Simple practices can make some difference, such as exercise or calorie restriction. But over the long haul all that really matters is progress in medicine: building new classes of therapy to repair and reverse the known root causes of aging. The sooner these treatments arrive, the more lives will be saved. Find out how to help »"

"The gut microbiome changes with age in ways the provoke chronic inflammation and tissue dysfunction. Animal studies demonstrate that restoring a youthful gut microbiome to old individuals extends life and improves health. Thus we would expect favorable changes to the gut microbiome to be reflected in any good alternative measure of aging, such as aging clocks. With that in mind, in today's open access paper the authors report on the development of algorithms based on gut microbiome composition that are predictive of epigenetic clock results. This allows identification of specific microbial species that may be harmful or helpful in the matter of the pace of aging."

"The eventual destination for this field of research is to produce probiotic or other forms of therapy that can permanently adjust the composition of the gut microbiome in a controlled way. Reduce the numbers of bad species, increase the numbers of good species, and do this for at least hundreds of different species. At present a number of approaches can rejuvenate the gut microbiome with a single treatment, but in an uncontrolled way. For example, fecal microbiota transplantation from a young donor. Animal studies show that fecal microbiota transplantation produces sizable benefits, but for human medicine, given the present regulatory environment, widespread use of such a gut microbiome altering therapy is only likely given complete control over both the contents of the therapy and the outcomes of the therapy."

"Gut microbiome signatures associate with DNA methylation-based biological aging"

Key Topics & Focus Areas for fightaging.org:

Gut Microbiome Composition Correlates with Epigenetic Clock Results

A View of Aging Centered Around the Role of Karyopherins and Nuclear Transport

Reviewing Age-Related Changes in Microglia

Quantifying the Risk of Alzheimer's Disease Associated with High Levels of p-tau217 in Blood

How to Go About Measuring Health in Aging is its Own Sizable Debate

CMLase Enzyme Developed to Break Down CML Advanced Glycation Endproducts